Molecular Docking Analysis of Ficus religiosa Active Compound with Anti-Inflammatory Activity by Targeting Tumour Necrosis Factor Alpha and Vascular Endothelial Growth Factor Receptor in Diabetic Wound Healing

BACKGROUND: Diabetes mellitus contributes to the delayed healing of wounds causes disturbance inflammatory cytokine. Tumour necrosis factor alpha (TNF-alpha) and Vascular Endothelial Growth Factor Receptor (VEGFR) both have a role in persistent inflammation associated with diabetic wounds. Ficus religiosa has developed reputation as traditional wound healer among some java people Indonesia. AIM: Our study aims discover molecular interaction between active constituents F. TNF-alpha VEGFR. MATERIALS AND METHODS: This research was conducted computerized docking using Protein database, Pymol, Discovery studio, Pyrex software. A thorough literature search identify potential compound target for Analysis its anti-inflammatory properties also carried out passonline webserver. Pharmacokinetic analysis performed Lipinski Rule Five websites PreADMET website. RESULTS: Each study’s compounds good pharmacokinetic profile. The predictions compound’s structure indicate that it strong impact. Lupenyl acetate Lanosterol bind more strongly than natural ligand, but Piperine binds CONCLUSIONS: acetate, Lanosterol, effects through inhibition In addition, this become drug because pharmacokinetics. Future studies are required determine effectiveness toxicity treatment